diff --git a/frontend/src/utils/verified-models.ts b/frontend/src/utils/verified-models.ts
index 12453c6c86..5b2e19e9ef 100644
--- a/frontend/src/utils/verified-models.ts
+++ b/frontend/src/utils/verified-models.ts
@@ -59,6 +59,7 @@ export const VERIFIED_ANTHROPIC_MODELS = [
   "claude-haiku-4-5-20251001",
   "claude-opus-4-20250514",
   "claude-opus-4-1-20250805",
+  "claude-opus-4-5-20251101",
 ];
 
 // LiteLLM does not return the compatible Mistral models with the provider, so we list them here to set them ourselves
diff --git a/openhands/llm/llm.py b/openhands/llm/llm.py
index b94ed3bc2b..150fa54925 100644
--- a/openhands/llm/llm.py
+++ b/openhands/llm/llm.py
@@ -188,12 +188,14 @@ class LLM(RetryMixin, DebugMixin):
         if 'claude-opus-4-1' in self.config.model.lower():
             kwargs['thinking'] = {'type': 'disabled'}
 
-        # Anthropic constraint: Opus 4.1 and Sonnet 4 models cannot accept both temperature and top_p
+        # Anthropic constraint: Opus 4.1, Opus 4.5, and Sonnet 4 models cannot accept both temperature and top_p
         # Prefer temperature (drop top_p) if both are specified.
         _model_lower = self.config.model.lower()
-        # Apply to Opus 4.1 and Sonnet 4 models to avoid API errors
+        # Apply to Opus 4.1, Opus 4.5, and Sonnet 4 models to avoid API errors
         if (
-            ('claude-opus-4-1' in _model_lower) or ('claude-sonnet-4' in _model_lower)
+            ('claude-opus-4-1' in _model_lower)
+            or ('claude-opus-4-5' in _model_lower)
+            or ('claude-sonnet-4' in _model_lower)
         ) and ('temperature' in kwargs and 'top_p' in kwargs):
             kwargs.pop('top_p', None)
 
diff --git a/tests/unit/llm/test_llm.py b/tests/unit/llm/test_llm.py
index dfdb4e05b4..b04425e631 100644
--- a/tests/unit/llm/test_llm.py
+++ b/tests/unit/llm/test_llm.py
@@ -1255,6 +1255,25 @@ def test_opus_41_keeps_temperature_top_p(mock_completion):
     assert 'top_p' not in call_kwargs
 
 
+@patch('openhands.llm.llm.litellm_completion')
+def test_opus_45_keeps_temperature_drops_top_p(mock_completion):
+    mock_completion.return_value = {
+        'choices': [{'message': {'content': 'ok'}}],
+    }
+    config = LLMConfig(
+        model='anthropic/claude-opus-4-5-20251101',
+        api_key='k',
+        temperature=0.7,
+        top_p=0.9,
+    )
+    llm = LLM(config, service_id='svc')
+    llm.completion(messages=[{'role': 'user', 'content': 'hi'}])
+    call_kwargs = mock_completion.call_args[1]
+    assert call_kwargs.get('temperature') == 0.7
+    # Anthropic rejects both temperature and top_p together on Opus 4.5; we keep temperature and drop top_p
+    assert 'top_p' not in call_kwargs
+
+
 @patch('openhands.llm.llm.litellm_completion')
 def test_sonnet_4_keeps_temperature_drops_top_p(mock_completion):
     mock_completion.return_value = {