diff --git a/.github/scripts/update_pr_description.sh b/.github/scripts/update_pr_description.sh
new file mode 100755
index 0000000000..04fe71109a
--- /dev/null
+++ b/.github/scripts/update_pr_description.sh
@@ -0,0 +1,49 @@
+#!/bin/bash
+
+# This script updates the PR description with commands to run the PR locally
+# It adds both Docker and uvx commands
+
+# Get the branch name for the PR
+BRANCH_NAME=$(gh pr view $PR_NUMBER --json headRefName --jq .headRefName)
+
+# Define the Docker command
+DOCKER_RUN_COMMAND="docker run -it --rm \
+  -p 3000:3000 \
+  -v /var/run/docker.sock:/var/run/docker.sock \
+  --add-host host.docker.internal:host-gateway \
+  -e SANDBOX_RUNTIME_CONTAINER_IMAGE=docker.all-hands.dev/all-hands-ai/runtime:$SHORT_SHA-nikolaik \
+  --name openhands-app-$SHORT_SHA \
+  docker.all-hands.dev/all-hands-ai/openhands:$SHORT_SHA"
+
+# Define the uvx command
+UVX_RUN_COMMAND="uvx --python 3.12 --from git+https://github.com/All-Hands-AI/OpenHands@$BRANCH_NAME openhands"
+
+# Get the current PR body
+PR_BODY=$(gh pr view $PR_NUMBER --json body --jq .body)
+
+# Prepare the new PR body with both commands
+if echo "$PR_BODY" | grep -q "To run this PR locally, use the following command:"; then
+  # For existing PR descriptions, replace the command section
+  NEW_PR_BODY=$(echo "$PR_BODY" | sed "s|To run this PR locally, use the following command:.*\`\`\`|To run this PR locally, use the following command:\n\nGUI with Docker:\n\`\`\`\n$DOCKER_RUN_COMMAND\n\`\`\`\n\nCLI with uvx:\n\`\`\`\n$UVX_RUN_COMMAND\n\`\`\`|s")
+else
+  # For new PR descriptions
+  NEW_PR_BODY="${PR_BODY}
+
+---
+
+To run this PR locally, use the following command:
+
+GUI with Docker:
+\`\`\`
+$DOCKER_RUN_COMMAND
+\`\`\`
+
+CLI with uvx:
+\`\`\`
+$UVX_RUN_COMMAND
+\`\`\`"
+fi
+
+# Update the PR description
+echo "Updating PR description with Docker and uvx commands"
+gh pr edit $PR_NUMBER --body "$NEW_PR_BODY"
diff --git a/.github/workflows/ghcr-build.yml b/.github/workflows/ghcr-build.yml
index bfe4db3e99..74f67b6e69 100644
--- a/.github/workflows/ghcr-build.yml
+++ b/.github/workflows/ghcr-build.yml
@@ -332,29 +332,5 @@ jobs:
           SHORT_SHA: ${{ steps.short_sha.outputs.SHORT_SHA }}
         shell: bash
         run: |
-          echo "updating PR description"
-          DOCKER_RUN_COMMAND="docker run -it --rm \
-            -p 3000:3000 \
-            -v /var/run/docker.sock:/var/run/docker.sock \
-            --add-host host.docker.internal:host-gateway \
-            -e SANDBOX_RUNTIME_CONTAINER_IMAGE=docker.all-hands.dev/all-hands-ai/runtime:$SHORT_SHA-nikolaik \
-            --name openhands-app-$SHORT_SHA \
-            docker.all-hands.dev/all-hands-ai/openhands:$SHORT_SHA"
-
-          PR_BODY=$(gh pr view $PR_NUMBER --json body --jq .body)
-
-          if echo "$PR_BODY" | grep -q "To run this PR locally, use the following command:"; then
-            UPDATED_PR_BODY=$(echo "${PR_BODY}" | sed -E "s|docker run -it --rm.*|$DOCKER_RUN_COMMAND|")
-          else
-            UPDATED_PR_BODY="${PR_BODY}
-
-          ---
-
-          To run this PR locally, use the following command:
-          \`\`\`
-          $DOCKER_RUN_COMMAND
-          \`\`\`"
-          fi
-
-          echo "updated body: $UPDATED_PR_BODY"
-          gh pr edit $PR_NUMBER --body "$UPDATED_PR_BODY"
+          echo "Updating PR description with Docker and uvx commands"
+          bash ${GITHUB_WORKSPACE}/.github/scripts/update_pr_description.sh