diff --git a/manifest/armv7l/p/py3_cryptography.filelist b/manifest/armv7l/p/py3_cryptography.filelist
index 74f8a260d4..9ef44cfd4c 100644
--- a/manifest/armv7l/p/py3_cryptography.filelist
+++ b/manifest/armv7l/p/py3_cryptography.filelist
@@ -1,12 +1,12 @@
-# Total size: 4207768
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/INSTALLER
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/METADATA
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/RECORD
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/REQUESTED
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/WHEEL
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/licenses/LICENSE
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/licenses/LICENSE.APACHE
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/licenses/LICENSE.BSD
+# Total size: 4516403
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/INSTALLER
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/METADATA
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/RECORD
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/REQUESTED
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/WHEEL
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/licenses/LICENSE
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/licenses/LICENSE.APACHE
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/licenses/LICENSE.BSD
 /usr/local/lib/python3.13/site-packages/cryptography/__about__.py
 /usr/local/lib/python3.13/site-packages/cryptography/__init__.py
 /usr/local/lib/python3.13/site-packages/cryptography/__pycache__/__about__.cpython-313.pyc
@@ -20,6 +20,10 @@
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/__pycache__/__init__.cpython-313.pyc
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/__pycache__/_oid.cpython-313.pyc
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/_oid.py
+/usr/local/lib/python3.13/site-packages/cryptography/hazmat/asn1/__init__.py
+/usr/local/lib/python3.13/site-packages/cryptography/hazmat/asn1/__pycache__/__init__.cpython-313.pyc
+/usr/local/lib/python3.13/site-packages/cryptography/hazmat/asn1/__pycache__/asn1.cpython-313.pyc
+/usr/local/lib/python3.13/site-packages/cryptography/hazmat/asn1/asn1.py
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/backends/__init__.py
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/backends/__pycache__/__init__.cpython-313.pyc
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/backends/openssl/__init__.py
@@ -32,6 +36,7 @@
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/bindings/_rust/__init__.pyi
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/bindings/_rust/_openssl.pyi
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/bindings/_rust/asn1.pyi
+/usr/local/lib/python3.13/site-packages/cryptography/hazmat/bindings/_rust/declarative_asn1.pyi
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/bindings/_rust/exceptions.pyi
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/bindings/_rust/ocsp.pyi
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/bindings/_rust/openssl/__init__.pyi
diff --git a/manifest/i686/p/py3_cryptography.filelist b/manifest/i686/p/py3_cryptography.filelist
index 51a93f3c05..fc5baf0b1c 100644
--- a/manifest/i686/p/py3_cryptography.filelist
+++ b/manifest/i686/p/py3_cryptography.filelist
@@ -1,12 +1,12 @@
-# Total size: 5222534
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/INSTALLER
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/METADATA
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/RECORD
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/REQUESTED
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/WHEEL
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/licenses/LICENSE
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/licenses/LICENSE.APACHE
-/usr/local/lib/python3.13/site-packages/cryptography-45.0.7.dist-info/licenses/LICENSE.BSD
+# Total size: 5610785
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/INSTALLER
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/METADATA
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/RECORD
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/REQUESTED
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/WHEEL
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/licenses/LICENSE
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/licenses/LICENSE.APACHE
+/usr/local/lib/python3.13/site-packages/cryptography-46.0.1.dist-info/licenses/LICENSE.BSD
 /usr/local/lib/python3.13/site-packages/cryptography/__about__.py
 /usr/local/lib/python3.13/site-packages/cryptography/__init__.py
 /usr/local/lib/python3.13/site-packages/cryptography/__pycache__/__about__.cpython-313.pyc
@@ -20,6 +20,10 @@
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/__pycache__/__init__.cpython-313.pyc
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/__pycache__/_oid.cpython-313.pyc
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/_oid.py
+/usr/local/lib/python3.13/site-packages/cryptography/hazmat/asn1/__init__.py
+/usr/local/lib/python3.13/site-packages/cryptography/hazmat/asn1/__pycache__/__init__.cpython-313.pyc
+/usr/local/lib/python3.13/site-packages/cryptography/hazmat/asn1/__pycache__/asn1.cpython-313.pyc
+/usr/local/lib/python3.13/site-packages/cryptography/hazmat/asn1/asn1.py
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/backends/__init__.py
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/backends/__pycache__/__init__.cpython-313.pyc
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/backends/openssl/__init__.py
@@ -32,6 +36,7 @@
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/bindings/_rust/__init__.pyi
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/bindings/_rust/_openssl.pyi
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/bindings/_rust/asn1.pyi
+/usr/local/lib/python3.13/site-packages/cryptography/hazmat/bindings/_rust/declarative_asn1.pyi
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/bindings/_rust/exceptions.pyi
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/bindings/_rust/ocsp.pyi
 /usr/local/lib/python3.13/site-packages/cryptography/hazmat/bindings/_rust/openssl/__init__.pyi
diff --git a/manifest/x86_64/p/py3_cryptography.filelist b/manifest/x86_64/p/py3_cryptography.filelist
index 3cb76804a5..595dd13c91 100644
--- a/manifest/x86_64/p/py3_cryptography.filelist
+++ b/manifest/x86_64/p/py3_cryptography.filelist
@@ -1,12 +1,12 @@
-# Total size: 11450660
-/usr/local/lib64/python3.13/site-packages/cryptography-45.0.7.dist-info/INSTALLER
-/usr/local/lib64/python3.13/site-packages/cryptography-45.0.7.dist-info/METADATA
-/usr/local/lib64/python3.13/site-packages/cryptography-45.0.7.dist-info/RECORD
-/usr/local/lib64/python3.13/site-packages/cryptography-45.0.7.dist-info/REQUESTED
-/usr/local/lib64/python3.13/site-packages/cryptography-45.0.7.dist-info/WHEEL
-/usr/local/lib64/python3.13/site-packages/cryptography-45.0.7.dist-info/licenses/LICENSE
-/usr/local/lib64/python3.13/site-packages/cryptography-45.0.7.dist-info/licenses/LICENSE.APACHE
-/usr/local/lib64/python3.13/site-packages/cryptography-45.0.7.dist-info/licenses/LICENSE.BSD
+# Total size: 11799072
+/usr/local/lib64/python3.13/site-packages/cryptography-46.0.1.dist-info/INSTALLER
+/usr/local/lib64/python3.13/site-packages/cryptography-46.0.1.dist-info/METADATA
+/usr/local/lib64/python3.13/site-packages/cryptography-46.0.1.dist-info/RECORD
+/usr/local/lib64/python3.13/site-packages/cryptography-46.0.1.dist-info/REQUESTED
+/usr/local/lib64/python3.13/site-packages/cryptography-46.0.1.dist-info/WHEEL
+/usr/local/lib64/python3.13/site-packages/cryptography-46.0.1.dist-info/licenses/LICENSE
+/usr/local/lib64/python3.13/site-packages/cryptography-46.0.1.dist-info/licenses/LICENSE.APACHE
+/usr/local/lib64/python3.13/site-packages/cryptography-46.0.1.dist-info/licenses/LICENSE.BSD
 /usr/local/lib64/python3.13/site-packages/cryptography/__about__.py
 /usr/local/lib64/python3.13/site-packages/cryptography/__init__.py
 /usr/local/lib64/python3.13/site-packages/cryptography/__pycache__/__about__.cpython-313.pyc
@@ -20,6 +20,10 @@
 /usr/local/lib64/python3.13/site-packages/cryptography/hazmat/__pycache__/__init__.cpython-313.pyc
 /usr/local/lib64/python3.13/site-packages/cryptography/hazmat/__pycache__/_oid.cpython-313.pyc
 /usr/local/lib64/python3.13/site-packages/cryptography/hazmat/_oid.py
+/usr/local/lib64/python3.13/site-packages/cryptography/hazmat/asn1/__init__.py
+/usr/local/lib64/python3.13/site-packages/cryptography/hazmat/asn1/__pycache__/__init__.cpython-313.pyc
+/usr/local/lib64/python3.13/site-packages/cryptography/hazmat/asn1/__pycache__/asn1.cpython-313.pyc
+/usr/local/lib64/python3.13/site-packages/cryptography/hazmat/asn1/asn1.py
 /usr/local/lib64/python3.13/site-packages/cryptography/hazmat/backends/__init__.py
 /usr/local/lib64/python3.13/site-packages/cryptography/hazmat/backends/__pycache__/__init__.cpython-313.pyc
 /usr/local/lib64/python3.13/site-packages/cryptography/hazmat/backends/openssl/__init__.py
@@ -32,6 +36,7 @@
 /usr/local/lib64/python3.13/site-packages/cryptography/hazmat/bindings/_rust/__init__.pyi
 /usr/local/lib64/python3.13/site-packages/cryptography/hazmat/bindings/_rust/_openssl.pyi
 /usr/local/lib64/python3.13/site-packages/cryptography/hazmat/bindings/_rust/asn1.pyi
+/usr/local/lib64/python3.13/site-packages/cryptography/hazmat/bindings/_rust/declarative_asn1.pyi
 /usr/local/lib64/python3.13/site-packages/cryptography/hazmat/bindings/_rust/exceptions.pyi
 /usr/local/lib64/python3.13/site-packages/cryptography/hazmat/bindings/_rust/ocsp.pyi
 /usr/local/lib64/python3.13/site-packages/cryptography/hazmat/bindings/_rust/openssl/__init__.pyi
diff --git a/packages/py3_cryptography.rb b/packages/py3_cryptography.rb
index 84f8da5478..1146163a5b 100644
--- a/packages/py3_cryptography.rb
+++ b/packages/py3_cryptography.rb
@@ -3,22 +3,21 @@ require 'buildsystems/pip'
 class Py3_cryptography < Pip
   description 'Cryptography provides cryptographic recipes and primitives to Python developers.'
   homepage 'https://cryptography.io/'
-  version "45.0.7-#{CREW_PY_VER}"
+  version "46.0.1-#{CREW_PY_VER}"
   license 'MIT'
   compatibility 'all'
   source_url 'SKIP'
   binary_compression 'tar.zst'
 
   binary_sha256({
-    aarch64: 'b0a2da7a89e67d61dd61c530facfd317dfda3e0c45e7bd21955803ec4d937134',
-     armv7l: 'b0a2da7a89e67d61dd61c530facfd317dfda3e0c45e7bd21955803ec4d937134',
-       i686: '03d33eea5037311bbb1deabe04f9401b0815006c3f90a710bd68cea6978f179e',
-     x86_64: '4d3ce78a8ff95269857fb66304697b256c342d818ab8f1ca356e515da80ff386'
+    aarch64: '9529c90399ea70cef497f0decd811fe800b165ff690ccb2ad592cb65f0f695d3',
+     armv7l: '9529c90399ea70cef497f0decd811fe800b165ff690ccb2ad592cb65f0f695d3',
+       i686: '5d409e710c8d248a392b1520c1405d7a3d75f3e320e37789047cf6affb7b777a',
+     x86_64: '1176b6b390ea5f8bbfc4047109dcfb53849d7315032894ed13fcda4ce9b765b7'
   })
 
   depends_on 'gcc_lib' # R
   depends_on 'glibc' # R
-  depends_on 'openssl' # R
   depends_on 'py3_cffi'
   depends_on 'py3_pycparser' => :build
   depends_on 'py3_typing_extensions'