diff --git a/lib/const.rb b/lib/const.rb
index 465e169cc..632e7c6dc 100644
--- a/lib/const.rb
+++ b/lib/const.rb
@@ -475,6 +475,7 @@ unless defined?(CREW_ANITYA_PACKAGE_NAME_MAPPINGS)
     { pkg_name: 'vidstab', anitya_pkg: 'vid.stab', comments: 'Prefer to GitHub' },
     { pkg_name: 'vim_runtime', anitya_pkg: 'vim', comments: '' },
     { pkg_name: 'wayland_info', anitya_pkg: 'wayland-utils', comments: '' },
+    { pkg_name: 'webkit2gtk_4_0', anitya_pkg: 'webkitgtk~stable', comments: '' },
     { pkg_name: 'webkit2gtk_4_1', anitya_pkg: 'webkitgtk~stable', comments: '' },
     { pkg_name: 'webkitgtk_6', anitya_pkg: 'webkitgtk~stable', comments: '' },
     { pkg_name: 'xauth', anitya_pkg: 'xorg-x11-xauth', comments: '' },
diff --git a/manifest/armv7l/w/webkit2gtk_4.filelist b/manifest/armv7l/w/webkit2gtk_4.filelist
index 8b5b9bcb7..1b7a9d168 100644
--- a/manifest/armv7l/w/webkit2gtk_4.filelist
+++ b/manifest/armv7l/w/webkit2gtk_4.filelist
@@ -1,4 +1,4 @@
-# Total size: 78884156
+# Total size: 102245191
 /usr/local/bin/WebKitWebDriver_4.0
 /usr/local/include/webkitgtk-4.0/JavaScriptCore/JSBase.h
 /usr/local/include/webkitgtk-4.0/JavaScriptCore/JSContextRef.h
@@ -90,6 +90,7 @@
 /usr/local/include/webkitgtk-4.0/webkit/WebKitWebEditor.h
 /usr/local/include/webkitgtk-4.0/webkit/WebKitWebExtension.h
 /usr/local/include/webkitgtk-4.0/webkit/WebKitWebExtensionAutocleanups.h
+/usr/local/include/webkitgtk-4.0/webkit/WebKitWebExtensionMatchPattern.h
 /usr/local/include/webkitgtk-4.0/webkit/WebKitWebFormManager.h
 /usr/local/include/webkitgtk-4.0/webkit/WebKitWebHitTestResult.h
 /usr/local/include/webkitgtk-4.0/webkit/WebKitWebInspector.h
@@ -224,15 +225,16 @@
 /usr/local/lib/girepository-1.0/WebKit2WebExtension-4.0.typelib
 /usr/local/lib/libjavascriptcoregtk-4.0.so
 /usr/local/lib/libjavascriptcoregtk-4.0.so.18
-/usr/local/lib/libjavascriptcoregtk-4.0.so.18.23.10
+/usr/local/lib/libjavascriptcoregtk-4.0.so.18.28.6
 /usr/local/lib/libwebkit2gtk-4.0.so
 /usr/local/lib/libwebkit2gtk-4.0.so.37
-/usr/local/lib/libwebkit2gtk-4.0.so.37.67.4
+/usr/local/lib/libwebkit2gtk-4.0.so.37.74.4
 /usr/local/lib/pkgconfig/javascriptcoregtk-4.0.pc
 /usr/local/lib/pkgconfig/webkit2gtk-4.0.pc
 /usr/local/lib/pkgconfig/webkit2gtk-web-extension-4.0.pc
 /usr/local/lib/webkit2gtk-4.0/injected-bundle/libwebkit2gtkinjectedbundle.so
 /usr/local/libexec/webkit2gtk-4.0/MiniBrowser
+/usr/local/libexec/webkit2gtk-4.0/WebKitGPUProcess
 /usr/local/libexec/webkit2gtk-4.0/WebKitNetworkProcess
 /usr/local/libexec/webkit2gtk-4.0/WebKitWebProcess
 /usr/local/libexec/webkit2gtk-4.0/jsc
diff --git a/manifest/x86_64/w/webkit2gtk_4.filelist b/manifest/x86_64/w/webkit2gtk_4.filelist
index def946c7b..933771cd2 100644
--- a/manifest/x86_64/w/webkit2gtk_4.filelist
+++ b/manifest/x86_64/w/webkit2gtk_4.filelist
@@ -1,4 +1,4 @@
-# Total size: 121829314
+# Total size: 146078029
 /usr/local/bin/WebKitWebDriver_4.0
 /usr/local/include/webkitgtk-4.0/JavaScriptCore/JSBase.h
 /usr/local/include/webkitgtk-4.0/JavaScriptCore/JSContextRef.h
@@ -90,6 +90,7 @@
 /usr/local/include/webkitgtk-4.0/webkit/WebKitWebEditor.h
 /usr/local/include/webkitgtk-4.0/webkit/WebKitWebExtension.h
 /usr/local/include/webkitgtk-4.0/webkit/WebKitWebExtensionAutocleanups.h
+/usr/local/include/webkitgtk-4.0/webkit/WebKitWebExtensionMatchPattern.h
 /usr/local/include/webkitgtk-4.0/webkit/WebKitWebFormManager.h
 /usr/local/include/webkitgtk-4.0/webkit/WebKitWebHitTestResult.h
 /usr/local/include/webkitgtk-4.0/webkit/WebKitWebInspector.h
@@ -224,15 +225,16 @@
 /usr/local/lib64/girepository-1.0/WebKit2WebExtension-4.0.typelib
 /usr/local/lib64/libjavascriptcoregtk-4.0.so
 /usr/local/lib64/libjavascriptcoregtk-4.0.so.18
-/usr/local/lib64/libjavascriptcoregtk-4.0.so.18.23.10
+/usr/local/lib64/libjavascriptcoregtk-4.0.so.18.28.6
 /usr/local/lib64/libwebkit2gtk-4.0.so
 /usr/local/lib64/libwebkit2gtk-4.0.so.37
-/usr/local/lib64/libwebkit2gtk-4.0.so.37.67.4
+/usr/local/lib64/libwebkit2gtk-4.0.so.37.74.4
 /usr/local/lib64/pkgconfig/javascriptcoregtk-4.0.pc
 /usr/local/lib64/pkgconfig/webkit2gtk-4.0.pc
 /usr/local/lib64/pkgconfig/webkit2gtk-web-extension-4.0.pc
 /usr/local/lib64/webkit2gtk-4.0/injected-bundle/libwebkit2gtkinjectedbundle.so
 /usr/local/libexec/webkit2gtk-4.0/MiniBrowser
+/usr/local/libexec/webkit2gtk-4.0/WebKitGPUProcess
 /usr/local/libexec/webkit2gtk-4.0/WebKitNetworkProcess
 /usr/local/libexec/webkit2gtk-4.0/WebKitWebProcess
 /usr/local/libexec/webkit2gtk-4.0/jsc
diff --git a/packages/webkit2gtk_4.rb b/packages/webkit2gtk_4.rb
index 979bd177d..5dfbc1d18 100644
--- a/packages/webkit2gtk_4.rb
+++ b/packages/webkit2gtk_4.rb
@@ -1,33 +1,36 @@
-require 'package'
+require 'buildsystems/cmake'
 
-class Webkit2gtk_4 < Package
+class Webkit2gtk_4 < CMake
   description 'Web content engine for GTK'
   homepage 'https://webkitgtk.org'
-  version '2.42.1'
+  version '2.50.1'
   license 'LGPL-2+ and BSD-2'
   compatibility 'aarch64 armv7l x86_64'
-  source_url 'https://webkitgtk.org/releases/webkitgtk-2.42.1.tar.xz'
-  source_sha256 '6f41fac9989d3ee51c08c48de1d439cdeddecbc757e34b6180987d99b16d2499'
+  source_url 'https://github.com/WebKit/WebKit.git'
+  git_hashtag "webkitgtk-#{version}"
+  # From the webkitglib/2.50 branch.
+  # git_hashtag '84fb745f2dec1b1f6417ee6059e76a60f6a4f96b'
+  # source_url "https://webkitgtk.org/releases/webkitgtk-#{version.split('-').first}.tar.xz"
+  # source_sha256 'e564b8099f9a3ae32409539b290bbd2ad084e99b6d22d4aac5e51e4554df8bc2'
   binary_compression 'tar.zst'
 
   binary_sha256({
-    aarch64: 'dfc34529afd99bd8c619757b4b3d7b837b819a8554fe291f5e936b09ed447133',
-     armv7l: 'dfc34529afd99bd8c619757b4b3d7b837b819a8554fe291f5e936b09ed447133',
-     x86_64: '6349949a24e1fbae37cb576454602287e136efb305ac7cd506a0ae84c6d26d98'
+    aarch64: '1b66a5f767a4adddbe8ac2afe674dece407738b70ffba198104f5958e9c1b4bf',
+     armv7l: '1b66a5f767a4adddbe8ac2afe674dece407738b70ffba198104f5958e9c1b4bf',
+     x86_64: '3ebd8287b6602a71b1c0a64c0de06bdc54b3733921c8b2416dd5cd3f5c1d4706'
   })
 
   depends_on 'at_spi2_core' # R
-  depends_on 'cairo'
-  depends_on 'ccache' => :build
-  depends_on 'dav1d'
+  depends_on 'cairo' # R
+  depends_on 'dav1d' => :build
   depends_on 'enchant' # R
+  depends_on 'expat' # R
   depends_on 'fontconfig'
   depends_on 'freetype' # R
-  depends_on 'gcc10' => :build
   depends_on 'gcc_lib' # R
   depends_on 'gdk_pixbuf' # R
-  depends_on 'glibc' # R
   depends_on 'glib' # R
+  depends_on 'glibc' # R
   depends_on 'gobject_introspection' => :build
   depends_on 'gstreamer' # R
   depends_on 'gtk3' # R
@@ -37,143 +40,112 @@ class Webkit2gtk_4 < Package
   depends_on 'icu4c' # R
   depends_on 'lcms' # R
   depends_on 'libavif' # R
+  depends_on 'libbacktrace' # R
   depends_on 'libdrm' # R
   depends_on 'libepoxy' # R
   depends_on 'libgcrypt' # R
-  depends_on 'libglvnd' # R
   depends_on 'libgpg_error' # R
   depends_on 'libjpeg_turbo' # R
   depends_on 'libjxl' # R
   depends_on 'libnotify'
   depends_on 'libpng' # R
   depends_on 'libsecret' # R
-  depends_on 'libsoup'
   depends_on 'libsoup2' # R
   depends_on 'libtasn1' # R
   depends_on 'libwebp' # R
-  depends_on 'libwpe' # R
   depends_on 'libx11' # R
-  depends_on 'libxcomposite' # R
-  depends_on 'libxdamage' # R
   depends_on 'libxml2' # R
-  depends_on 'libxrender' # R
   depends_on 'libxslt' # R
-  depends_on 'libxt' # R
   depends_on 'mesa' # R
-  depends_on 'openjpeg' # R
   depends_on 'pango' # R
   depends_on 'py3_gi_docgen' => :build
   depends_on 'py3_smartypants' => :build
   depends_on 'sqlite' # R
+  depends_on 'sysprof' => :build
   depends_on 'unifdef' => :build
   depends_on 'valgrind' => :build
-  depends_on 'vulkan_headers' => :build
   depends_on 'vulkan_icd_loader'
   depends_on 'wayland' # R
   depends_on 'woff2' # R
-  depends_on 'wpebackend_fdo' # R
   depends_on 'zlib' # R
 
+  cache_build
   no_env_options
+  no_lto
 
   def self.patch
     system "sed -i 's,/usr/bin,/usr/local/bin,g' Source/JavaScriptCore/inspector/scripts/codegen/preprocess.pl"
-    @arch_flags = ''
-    @gcc_ver = ''
-    if ARCH == 'armv7l' || ARCH == 'aarch64'
-      ## Patch from https://bugs.webkit.org/show_bug.cgi?id=226557#c27 to
-      ## handle issue with gcc > 11.
-      # @gcc_patch = <<~'GCCEOF'
-      # diff --git a/Source/cmake/WebKitCompilerFlags.cmake b/Source/cmake/WebKitCompilerFlags.cmake
-      # index 77ebb802ebb03450b5e96629a47b6819a68672c6..d49d6e43d7eeb6673c624e00eadf3edfca0674eb 100644
-      #--- a/Source/cmake/WebKitCompilerFlags.cmake
-      #+++ b/Source/cmake/WebKitCompilerFlags.cmake
-      # @@ -143,6 +143,13 @@ if (COMPILER_IS_GCC_OR_CLANG)
-      # WEBKIT_PREPEND_GLOBAL_CXX_FLAGS(-Wno-nonnull)
-      # endif ()
+  end
 
-      # +    # This triggers warnings in wtf/Packed.h, a header that is included in many places. It does not
-      # +    # respect ignore warning pragmas and we cannot easily suppress it for all affected files.
-      # +    # https://bugs.webkit.org/show_bug.cgi?id=226557
-      # +    if (CMAKE_CXX_COMPILER_ID MATCHES "GNU" AND ${CMAKE_CXX_COMPILER_VERSION} VERSION_GREATER_EQUAL "11.0")
-      # +        WEBKIT_PREPEND_GLOBAL_CXX_FLAGS(-Wno-stringop-overread)
-      # +    endif ()
-      # +
-      ## -Wexpansion-to-defined produces false positives with GCC but not Clang
-      ## https://bugs.webkit.org/show_bug.cgi?id=167643#c13
-      # if (CMAKE_CXX_COMPILER_ID MATCHES "GNU")
-      # GCCEOF
-      # File.write('gcc.patch', @gcc_patch)
-      # system 'patch -Np1 -F 10 -i gcc.patch'
-      # Patch from https://github.com/WebKit/WebKit/pull/1233
-      # downloader 'https://patch-diff.githubusercontent.com/raw/WebKit/WebKit/pull/1233.diff',
-      #           '70c990ced72c5551b01c9d7c72da7900d609d0f7891e7b99ab132ac1b4aa33ea'
-      # system "sed -i 's,data.pixels->bytes(),data.pixels->data(),' 1233.diff"
-      # system 'patch -Np1 -F 10 -i 1233.diff'
-      # Patch from https://github.com/WebKit/WebKit/pull/2926
-      # downloader 'https://patch-diff.githubusercontent.com/raw/WebKit/WebKit/pull/2926.diff',
-      # '26a8d5a9dd9d61865645158681b766e13cf05b3ed07f30bebb79ff73259d0664'
-      # system "sed -i '22,63d' 2926.diff"
-      # system 'patch -Np1 -F 10 -i 2926.diff'
-      # @arch_flags = '-mtune=cortex-a15 -mfloat-abi=hard -mfpu=neon -mtls-dialect=gnu -marm -mlibarch=armv8-a+crc+simd -march=armv8-a+crc+simd'
+  pre_cmake_options "CC=#{CREW_PREFIX}/bin/gcc CXX=#{CREW_PREFIX}/bin/g++"
+  cmake_options "-DCMAKE_BUILD_WITH_INSTALL_RPATH=ON \
+          -DENABLE_BUBBLEWRAP_SANDBOX=OFF \
+          -DENABLE_DOCUMENTATION=OFF \
+          -DENABLE_GAMEPAD=OFF \
+          -DENABLE_JOURNALD_LOG=OFF \
+          -DENABLE_MINIBROWSER=ON \
+          -DENABLE_SPEECH_SYNTHESIS=OFF \
+          -DPORT=GTK \
+          -DPYTHON_EXECUTABLE=`which python` \
+          -DUSER_AGENT_BRANDING='Chromebrew' \
+          -DUSE_GTK4=OFF \
+          -DUSE_JPEGXL=ON \
+          -DUSE_SOUP2=ON"
+  cmake_pre_cache_build_extras do
+    # This only works in the container.
+    system "sudo ln -sf #{CREW_PREFIX}/bin/gcc /usr/bin/gcc" if CREW_IN_CONTAINER
+    system "sudo ln -sf #{CREW_PREFIX}/bin/g++ /usr/bin/g++" if CREW_IN_CONTAINER
+    if ARCH == 'armv7l'
       @arch_flags = '-mfloat-abi=hard -mtls-dialect=gnu -mthumb -mfpu=vfpv3-d16 -mlibarch=armv7-a+fp -march=armv7-a+fp'
-    end
-    @gcc_ver = '-10'
-    @new_gcc = <<~NEW_GCCEOF
-      #!/bin/bash
-      gcc#{@gcc_ver} #{@arch_flags} $@
-    NEW_GCCEOF
-    @new_gpp = <<~NEW_GPPEOF
-      #!/bin/bash
-      g++#{@gcc_ver} #{@arch_flags} $@
-    NEW_GPPEOF
-    FileUtils.mkdir_p 'bin'
-    File.write('bin/gcc', @new_gcc)
-    FileUtils.chmod 0o755, 'bin/gcc'
-    File.write('bin/g++', @new_gpp)
-    FileUtils.chmod 0o755, 'bin/g++'
-  end
-
-  def self.build
-    # This builds webkit2gtk4 (which uses gtk3 and libsoup2)
-    @workdir = Dir.pwd
-    # Bubblewrap sandbox breaks on epiphany with
-    # bwrap: Can't make symlink at /var/run: File exists
-    # LDFLAGS from debian: -Wl,--no-keep-memory
-    unless File.file?('build.ninja')
-      @arch_linker_flags = ARCH == 'x86_64' ? '' : '-Wl,--no-keep-memory'
-      system "CREW_LINKER_FLAGS='#{@arch_linker_flags}' CC='#{@workdir}/bin/gcc' CXX='#{@workdir}/bin/g++' \
-            cmake -B builddir -G Ninja \
-            #{CREW_CMAKE_OPTIONS.sub('-pipe', '-pipe -Wno-error').gsub('-flto=auto', '').sub('-DCMAKE_INTERPROCEDURAL_OPTIMIZATION=TRUE', '')} \
-            -DCMAKE_BUILD_WITH_INSTALL_RPATH=ON \
-            -DENABLE_BUBBLEWRAP_SANDBOX=OFF \
-            -DENABLE_DOCUMENTATION=OFF \
-            -DENABLE_GLES2=OFF \
-            -DENABLE_JOURNALD_LOG=OFF \
-            -DENABLE_GAMEPAD=OFF \
-            -DENABLE_MINIBROWSER=ON \
-            -DUSE_SYSTEM_MALLOC=ON \
-            -DPORT=GTK \
-            -DUSE_JPEGXL=ON \
-            -DUSE_GTK4=OFF \
-            -DUSE_SOUP2=ON \
-            -DPYTHON_EXECUTABLE=`which python` \
-            -DUSER_AGENT_BRANDING='Chromebrew'"
-    end
-    @counter = 1
-    @counter_max = 20
-    loop do
-      break if Kernel.system "#{CREW_NINJA} -C builddir -j #{CREW_NPROC}"
-
-      puts "Make iteration #{@counter} of #{@counter_max}...".orange
-
-      @counter += 1
-      break if @counter > @counter_max
+      @new_gcc = <<~NEW_GCCEOF
+        #!/bin/bash
+        gcc #{@arch_flags} $@
+      NEW_GCCEOF
+      @new_gpp = <<~NEW_GPPEOF
+        #!/bin/bash
+        # See https://wiki.debian.org/ReduceBuildMemoryOverhead
+        g++ #{@arch_flags} --param ggc-min-expand=10 $@
+        # g++ #{@arch_flags} $@
+      NEW_GPPEOF
+      FileUtils.mkdir_p 'bin'
+      File.write('bin/gcc', @new_gcc)
+      FileUtils.chmod 0o755, 'bin/gcc'
+      File.write('bin/g++', @new_gpp)
+      FileUtils.chmod 0o755, 'bin/g++'
     end
   end
 
-  def self.install
-    system "DESTDIR=#{CREW_DEST_DIR} #{CREW_NINJA} -C builddir install"
+  if ARCH == 'armv7l'
+    def self.build
+      # This builds webkit2gtk4 (which uses gtk3 and libsoup2)
+      @workdir = Dir.pwd
+      # Bubblewrap sandbox breaks on epiphany with
+      # bwrap: Can't make symlink at /var/run: File exists
+      # LDFLAGS from debian: -Wl,--no-keep-memory
+      unless File.file?('build.ninja')
+        @arch_linker_flags = ARCH == 'x86_64' ? '' : '-Wl,--no-keep-memory'
+        system "CC='#{@workdir}/bin/gcc' CXX='#{@workdir}/bin/g++' CREW_LINKER_FLAGS='#{@arch_linker_flags}' \
+          cmake -B builddir -G Ninja \
+          #{CREW_CMAKE_OPTIONS.sub('-pipe', '-pipe -Wno-error').gsub('-flto=auto', '').sub('-DCMAKE_INTERPROCEDURAL_OPTIMIZATION=TRUE', '')} \
+          -DCMAKE_BUILD_WITH_INSTALL_RPATH=ON \
+          -DENABLE_BUBBLEWRAP_SANDBOX=OFF \
+          -DENABLE_DOCUMENTATION=OFF \
+          -DENABLE_GAMEPAD=OFF \
+          -DENABLE_JOURNALD_LOG=OFF \
+          -DENABLE_MINIBROWSER=ON \
+          -DENABLE_SPEECH_SYNTHESIS=OFF \
+          -DPORT=GTK \
+          -DPYTHON_EXECUTABLE=`which python` \
+          -DUSER_AGENT_BRANDING='Chromebrew' \
+          -DUSE_GTK4=OFF \
+          -DUSE_JPEGXL=ON \
+          -DUSE_SOUP2=ON"
+      end
+      Kernel.system "#{CREW_NINJA} -C builddir -j #{CREW_NPROC}"
+    end
+  end
+
+  cmake_install_extras do
     FileUtils.mv "#{CREW_DEST_PREFIX}/bin/WebKitWebDriver", "#{CREW_DEST_PREFIX}/bin/WebKitWebDriver_4.0"
   end
 end