diff --git a/.changeset/wet-beds-fold.md b/.changeset/wet-beds-fold.md
new file mode 100644
index 0000000000..91e67c2974
--- /dev/null
+++ b/.changeset/wet-beds-fold.md
@@ -0,0 +1,5 @@
+---
+"@directus/app": patch
+---
+
+Fixed incorrect endpoints for system collections
diff --git a/app/src/interfaces/translations/translations.vue b/app/src/interfaces/translations/translations.vue
index 4eba455d1a..b4e6af8f42 100644
--- a/app/src/interfaces/translations/translations.vue
+++ b/app/src/interfaces/translations/translations.vue
@@ -82,6 +82,7 @@ import { cloneDeep, isNil } from 'lodash';
 import { computed, ref, toRefs, watch } from 'vue';
 import { useI18n } from 'vue-i18n';
 import LanguageSelect from './language-select.vue';
+import { getEndpoint } from '@directus/utils';
 
 const props = withDefaults(
 	defineProps<{
@@ -291,7 +292,7 @@ function useLanguages() {
 
 		try {
 			languages.value = await fetchAll<Record<string, any>[]>(
-				`/items/${relationInfo.value.relatedCollection.collection}`,
+				getEndpoint(relationInfo.value.relatedCollection.collection),
 				{
 					params: {
 						fields: Array.from(fields),
diff --git a/app/src/layouts/calendar/index.ts b/app/src/layouts/calendar/index.ts
index 8691db6deb..a30afc7e8a 100644
--- a/app/src/layouts/calendar/index.ts
+++ b/app/src/layouts/calendar/index.ts
@@ -3,6 +3,7 @@ import { router } from '@/router';
 import { useAppStore } from '@/stores/app';
 import { useServerStore } from '@/stores/server';
 import { getFullcalendarLocale } from '@/utils/get-fullcalendar-locale';
+import { getItemRoute } from '@/utils/get-item-route';
 import { renderDisplayStringTemplate } from '@/utils/render-string-template';
 import { saveAsCSV } from '@/utils/save-as-csv';
 import { syncRefProperty } from '@/utils/sync-ref-property';
@@ -176,11 +177,7 @@ export default defineLayout<LayoutOptions>({
 					} else {
 						const primaryKey = info.event.id;
 
-						const route = collection.value.startsWith('directus_')
-							? collection.value.substring(9)
-							: `content/${collection.value}`;
-
-						router.push(`/${route}/${primaryKey}`);
+						router.push(getItemRoute(collection.value, primaryKey));
 					}
 				},
 				async eventChange(info) {
diff --git a/app/src/layouts/kanban/index.ts b/app/src/layouts/kanban/index.ts
index 90bf3a31d0..25ae7bfa6a 100644
--- a/app/src/layouts/kanban/index.ts
+++ b/app/src/layouts/kanban/index.ts
@@ -6,7 +6,7 @@ import { getRootPath } from '@/utils/get-root-path';
 import { translate } from '@/utils/translate-literal';
 import { useCollection, useFilterFields, useItems, useSync } from '@directus/composables';
 import { User } from '@directus/types';
-import { defineLayout, getRelationType, moveInArray } from '@directus/utils';
+import { defineLayout, getEndpoint, getRelationType, moveInArray } from '@directus/utils';
 import { computed, ref, toRefs, watch } from 'vue';
 import KanbanActions from './actions.vue';
 import KanbanLayout from './kanban.vue';
@@ -255,7 +255,7 @@ export default defineLayout<LayoutOptions, LayoutQuery>({
 			const gField = groupField.value;
 			const pkField = primaryKeyField.value?.field;
 
-			if (gField === null || pkField === undefined || event.removed) return;
+			if (gField === null || pkField === undefined || event.removed || !collection.value) return;
 
 			if (event.moved) {
 				const item = group.items[event.moved.oldIndex]?.id;
@@ -288,7 +288,7 @@ export default defineLayout<LayoutOptions, LayoutQuery>({
 					}
 				}
 
-				await api.patch(`/items/${collection.value}/${event.added.element.id}`, {
+				await api.patch(`${getEndpoint(collection.value)}/${event.added.element.id}`, {
 					[gField]: group.id,
 				});
 			}
@@ -459,19 +459,19 @@ export default defineLayout<LayoutOptions, LayoutQuery>({
 			async function deleteGroup(id: string | number) {
 				const pkField = primaryKeyField.value?.field;
 
-				if (pkField === undefined) return;
+				if (pkField === undefined || !groupsCollection.value) return;
 
 				items.value = items.value.filter((item) => item[pkField] !== id);
 
-				await api.delete(`/items/${groupsCollection.value}/${id}`);
+				await api.delete(`${getEndpoint(groupsCollection.value)}/${id}`);
 
 				await getGroups();
 			}
 
 			async function addGroup(title: string) {
-				if (groupTitle.value === null) return;
+				if (groupTitle.value === null || !groupsCollection.value) return;
 
-				await api.post(`/items/${groupsCollection.value}`, {
+				await api.post(getEndpoint(groupsCollection.value), {
 					[groupTitle.value]: title,
 				});
 
@@ -480,9 +480,9 @@ export default defineLayout<LayoutOptions, LayoutQuery>({
 
 			async function editGroup(id: string | number, title: string) {
 				if (isRelational.value) {
-					if (groupTitle.value === null) return;
+					if (groupTitle.value === null || !groupsCollection.value) return;
 
-					await api.patch(`/items/${groupsCollection.value}/${id}`, {
+					await api.patch(`${getEndpoint(groupsCollection.value)}/${id}`, {
 						[groupTitle.value]: title,
 					});
 				} else {
diff --git a/app/src/layouts/kanban/kanban.vue b/app/src/layouts/kanban/kanban.vue
index 8e7091d0be..9c85fab687 100644
--- a/app/src/layouts/kanban/kanban.vue
+++ b/app/src/layouts/kanban/kanban.vue
@@ -50,7 +50,7 @@
 						@change="change(group, $event)"
 					>
 						<template #item="{ element }">
-							<router-link :to="`${collection}/${element.id}`" class="item">
+							<router-link :to="getItemRoute(collection, element.id)" class="item">
 								<div v-if="element.title" class="title">{{ element.title }}</div>
 								<img v-if="element.image" class="image" :src="element.image" />
 								<div v-if="element.text" class="text">{{ element.text }}</div>
@@ -110,6 +110,7 @@ export default {
 <script setup lang="ts">
 import { addTokenToURL } from '@/api';
 import { getRootPath } from '@/utils/get-root-path';
+import { getItemRoute } from '@/utils/get-item-route';
 import { ref } from 'vue';
 import { useI18n } from 'vue-i18n';
 import Draggable from 'vuedraggable';
diff --git a/app/src/modules/settings/routes/data-model/field-detail/store/index.ts b/app/src/modules/settings/routes/data-model/field-detail/store/index.ts
index 6abd36efd2..14e24e4686 100644
--- a/app/src/modules/settings/routes/data-model/field-detail/store/index.ts
+++ b/app/src/modules/settings/routes/data-model/field-detail/store/index.ts
@@ -13,6 +13,7 @@ import * as alterations from './alterations';
 import { getLocalTypeForField } from '@/utils/get-local-type';
 import api from '@/api';
 import { useExtensions } from '@/extensions';
+import { getEndpoint } from '@directus/utils';
 
 export function syncFieldDetailStoreProperty(path: string, defaultValue?: any) {
 	const fieldDetailStore = useFieldDetailStore();
@@ -223,7 +224,7 @@ export const useFieldDetailStore = defineStore({
 				}
 
 				for (const collection of Object.keys(this.items)) {
-					await api.post(`/items/${collection}`, this.items[collection]);
+					await api.post(getEndpoint(collection), this.items[collection]);
 				}
 
 				await fieldsStore.hydrate();
diff --git a/app/src/utils/get-item-route.test.ts b/app/src/utils/get-item-route.test.ts
new file mode 100644
index 0000000000..6f227353cf
--- /dev/null
+++ b/app/src/utils/get-item-route.test.ts
@@ -0,0 +1,27 @@
+import { describe, expect, it } from 'vitest';
+
+import { getItemRoute } from '@/utils/get-item-route';
+
+const collection = 'some_collection';
+const systemCollection = 'directus_users';
+const primaryKeys = [123, 'abc'];
+
+describe('getItemRoute', () => {
+	it('Returns an empty string when collection is null', () => {
+		for (const primaryKey of primaryKeys) {
+			expect(getItemRoute(null, primaryKey)).toBe('');
+		}
+	});
+
+	it('Returns the expected route for collection', () => {
+		for (const primaryKey of primaryKeys) {
+			expect(getItemRoute(collection, primaryKey)).toBe(`/content/${collection}/${primaryKey}`);
+		}
+	});
+
+	it('Returns the expected route for system collection', () => {
+		for (const primaryKey of primaryKeys) {
+			expect(getItemRoute(systemCollection, primaryKey)).toBe(`/${systemCollection.substring(9)}/${primaryKey}`);
+		}
+	});
+});
diff --git a/app/src/utils/get-item-route.ts b/app/src/utils/get-item-route.ts
new file mode 100644
index 0000000000..bb9446f3b0
--- /dev/null
+++ b/app/src/utils/get-item-route.ts
@@ -0,0 +1,14 @@
+/**
+ * Get the route of an item in the admin app for a given collection and primary key
+ *
+ * @param collection - Collection name
+ * @param primaryKey - Primary key of item
+ * @returns - URL route for the item
+ */
+export function getItemRoute(collection: string | null, primaryKey: string | number) {
+	if (collection === null) return '';
+
+	const route = collection.startsWith('directus_') ? collection.substring(9) : `content/${collection}`;
+
+	return `/${route}/${primaryKey}`;
+}