diff --git a/packages/react-fast-refresh/client-runtime.js b/packages/react-fast-refresh/client-runtime.js
index c65aff1ad7..d0feab6ec0 100644
--- a/packages/react-fast-refresh/client-runtime.js
+++ b/packages/react-fast-refresh/client-runtime.js
@@ -1,6 +1,11 @@
-const enabled = __meteor_runtime_config__.reactFastRefreshEnabled;
+let initialized = false;
+
+window.___INIT_METEOR_FAST_REFRESH = function init() {
+  if (initialized) {
+    return;
+  }
+  initialized = true;
 
-if (enabled && process.env.NODE_ENV !== 'production' && module.hot) {
   const runtime = require('react-refresh/runtime');
 
   let timeout = null;
@@ -113,3 +118,10 @@ if (enabled && process.env.NODE_ENV !== 'production' && module.hot) {
     }
   });
 }
+
+if (
+  __meteor_runtime_config__ &&
+  __meteor_runtime_config__.reactFastRefreshEnabled
+) {
+  window.___INIT_METEOR_FAST_REFRESH();
+}
diff --git a/packages/react-fast-refresh/server.js b/packages/react-fast-refresh/server.js
index 1fde5134d8..ac24948182 100644
--- a/packages/react-fast-refresh/server.js
+++ b/packages/react-fast-refresh/server.js
@@ -1,20 +1,20 @@
-
 let enabled = !process.env.DISABLE_REACT_FAST_REFRESH;
 
 if (enabled) {
   try {
     // React fast refresh requires react 16.9.0 or newer
-    const semver = require('semver');
+    const semverGte = require('semver/functions/gte');
     const pkg = require('react/package.json');
 
     enabled = pkg && pkg.version &&
-      semver.gte(pkg.version, '16.9.0');
+      semverGte(pkg.version, '16.9.0');
   } catch (e) {
     // If the app doesn't directly depend on react, leave react-refresh
     // enabled in case a package or indirect dependency uses react.
   }
 }
 
+// Needed for compatibility when build plugins use ReactFastRefresh.babelPlugin
 if (typeof __meteor_runtime_config__ === 'object') {
   __meteor_runtime_config__.reactFastRefreshEnabled = enabled;
 }
@@ -23,6 +23,48 @@ const babelPlugin = enabled ?
   require('react-refresh/babel') :
   null;
 
+// Babel plugin that adds a call to global.___INIT_METEOR_FAST_REFRESH()
+// at the start of every file compiled with react-refresh to ensure the runtime
+// is enabled if it is used.
+function enableReactRefreshBabelPlugin(babel) {
+  const { types: t } = babel;
+
+  return {
+    name: "meteor-enable-react-fast-refresh",
+    post(state) {
+      // This is the path for the Program node
+      let path = state.path;
+      let method = t.identifier("___INIT_METEOR_FAST_REFRESH");
+      let call = t.callExpression(
+        t.memberExpression(t.identifier('global'), method),
+        []
+      );
+      path.unshiftContainer("body", t.expressionStatement(call));
+    },
+  };
+}
+
+let deprecationWarned = false;
+
 ReactFastRefresh = {
-  babelPlugin,
+  get babelPlugin() {
+    if (!deprecationWarned) {
+      console.warn(
+        'ReactFastRefresh.babelPlugin is deprecated and is incompatible with HMR on Cordova. Use ReactFastRefresh.getBabelPlugins() instead.'
+      );
+      deprecationWarned = true;
+    }
+
+    return babelPlugin;
+  },
+  getBabelPlugins() {
+    if (!babelPlugin) {
+      return [];
+    }
+
+    return [
+      babelPlugin,
+      enableReactRefreshBabelPlugin,
+    ]
+  }
 };