diff --git a/testing/endtoend/endtoend_setup_test.go b/testing/endtoend/endtoend_setup_test.go
index 8afb161d80..7782a76750 100644
--- a/testing/endtoend/endtoend_setup_test.go
+++ b/testing/endtoend/endtoend_setup_test.go
@@ -19,9 +19,9 @@ func e2eMinimal(t *testing.T, v int, cfgo ...types.E2EConfigOpt) *testRunner {
 	require.NoError(t, params.SetActive(types.StartAt(v, params.E2ETestConfig())))
 	require.NoError(t, e2eParams.Init(t, e2eParams.StandardBeaconCount))
 
-	// Run for 14 epochs if not in long-running to confirm long-running has no issues.
+	// Run for 12 epochs if not in long-running to confirm long-running has no issues.
 	var err error
-	epochsToRun := 14
+	epochsToRun := 12
 	epochStr, longRunning := os.LookupEnv("E2E_EPOCHS")
 	if longRunning {
 		epochsToRun, err = strconv.Atoi(epochStr)
@@ -56,7 +56,7 @@ func e2eMinimal(t *testing.T, v int, cfgo ...types.E2EConfigOpt) *testRunner {
 		ev.AltairForkTransition,
 		ev.BellatrixForkTransition,
 		ev.CapellaForkTransition,
-		ev.DenebForkTransition,
+		// ev.DenebForkTransition, // TODO(12750): Enable this when geth main branch's engine API support.
 		ev.APIMiddlewareVerifyIntegrity,
 		ev.APIGatewayV1Alpha1VerifyIntegrity,
 		ev.FinishedSyncing,
@@ -133,7 +133,7 @@ func e2eMainnet(t *testing.T, usePrysmSh, useMultiClient bool, cfg *params.Beaco
 		ev.AltairForkTransition,
 		ev.BellatrixForkTransition,
 		ev.CapellaForkTransition,
-		ev.DenebForkTransition,
+		// ev.DenebForkTransition, // TODO(12750): Enable this when geth main branch's engine API support.
 		ev.APIMiddlewareVerifyIntegrity,
 		ev.APIGatewayV1Alpha1VerifyIntegrity,
 		ev.FinishedSyncing,
@@ -190,7 +190,7 @@ func scenarioEvals() []types.Evaluator {
 		ev.AltairForkTransition,
 		ev.BellatrixForkTransition,
 		ev.CapellaForkTransition,
-		ev.DenebForkTransition,
+		// ev.DenebForkTransition, // TODO(12750): Enable this when geth main branch's engine API support.
 		ev.APIMiddlewareVerifyIntegrity,
 		ev.APIGatewayV1Alpha1VerifyIntegrity,
 		ev.FinishedSyncing,
@@ -212,7 +212,7 @@ func scenarioEvalsMulti() []types.Evaluator {
 		ev.AltairForkTransition,
 		ev.BellatrixForkTransition,
 		ev.CapellaForkTransition,
-		ev.DenebForkTransition,
+		// ev.DenebForkTransition, // TODO(12750): Enable this when geth main branch's engine API support.
 		ev.APIMiddlewareVerifyIntegrity,
 		ev.APIGatewayV1Alpha1VerifyIntegrity,
 		ev.FinishedSyncing,
diff --git a/testing/endtoend/evaluators/fork.go b/testing/endtoend/evaluators/fork.go
index f4e0823e17..54d4499be0 100644
--- a/testing/endtoend/evaluators/fork.go
+++ b/testing/endtoend/evaluators/fork.go
@@ -47,12 +47,6 @@ var CapellaForkTransition = types.Evaluator{
 	Evaluation: capellaForkOccurs,
 }
 
-var DenebForkTransition = types.Evaluator{
-	Name:       "deneb_fork_transition_%d",
-	Policy:     policies.OnEpoch(helpers.DenebE2eForkEpoch),
-	Evaluation: denebForkOccurs,
-}
-
 func altairForkOccurs(_ *types.EvaluationContext, conns ...*grpc.ClientConn) error {
 	conn := conns[0]
 	client := ethpb.NewBeaconNodeValidatorClient(conn)
@@ -182,46 +176,3 @@ func capellaForkOccurs(_ *types.EvaluationContext, conns ...*grpc.ClientConn) er
 	}
 	return nil
 }
-
-func denebForkOccurs(_ *types.EvaluationContext, conns ...*grpc.ClientConn) error {
-	conn := conns[0]
-	client := ethpb.NewBeaconNodeValidatorClient(conn)
-	ctx, cancel := context.WithTimeout(context.Background(), streamDeadline)
-	defer cancel()
-	stream, err := client.StreamBlocksAltair(ctx, &ethpb.StreamBlocksRequest{VerifiedOnly: true})
-	if err != nil {
-		return errors.Wrap(err, "failed to get stream")
-	}
-	fSlot, err := slots.EpochStart(helpers.DenebE2eForkEpoch)
-	if err != nil {
-		return err
-	}
-	if ctx.Err() == context.Canceled {
-		return errors.New("context canceled prematurely")
-	}
-	res, err := stream.Recv()
-	if err != nil {
-		return err
-	}
-	if res == nil || res.Block == nil {
-		return errors.New("nil block returned by beacon node")
-	}
-
-	if res.GetBlock() == nil {
-		return errors.New("nil block returned by beacon node")
-	}
-	if res.GetDenebBlock() == nil {
-		return errors.Errorf("non-capella block returned after the fork with type %T", res.Block)
-	}
-	blk, err := blocks.NewSignedBeaconBlock(res.GetDenebBlock())
-	if err != nil {
-		return err
-	}
-	if err := blocks.BeaconBlockIsNil(blk); err != nil {
-		return err
-	}
-	if blk.Block().Slot() < fSlot {
-		return errors.Errorf("wanted a block at slot >= %d but received %d", fSlot, blk.Block().Slot())
-	}
-	return nil
-}
diff --git a/testing/endtoend/helpers/helpers.go b/testing/endtoend/helpers/helpers.go
index a7e2be4f29..66a397ec68 100644
--- a/testing/endtoend/helpers/helpers.go
+++ b/testing/endtoend/helpers/helpers.go
@@ -40,7 +40,6 @@ const (
 	AltairE2EForkEpoch    = params.AltairE2EForkEpoch
 	BellatrixE2EForkEpoch = params.BellatrixE2EForkEpoch
 	CapellaE2EForkEpoch   = params.CapellaE2EForkEpoch
-	DenebE2eForkEpoch     = params.DenebE2EForkEpoch
 )
 
 // Graffiti is a list of sample graffiti strings.