diff --git a/beacon-chain/node/config.go b/beacon-chain/node/config.go
index 3c943995f8..503ed8dae5 100644
--- a/beacon-chain/node/config.go
+++ b/beacon-chain/node/config.go
@@ -100,7 +100,7 @@ func configureEth1Config(cliCtx *cli.Context) error {
 }
 
 func configureNetwork(cliCtx *cli.Context) {
-	if cliCtx.IsSet(cmd.BootstrapNode.Name) {
+	if len(cliCtx.StringSlice(cmd.BootstrapNode.Name)) > 0 {
 		c := params.BeaconNetworkConfig()
 		c.BootstrapNodes = cliCtx.StringSlice(cmd.BootstrapNode.Name)
 		params.OverrideBeaconNetworkConfig(c)
diff --git a/beacon-chain/node/config_test.go b/beacon-chain/node/config_test.go
index e001b5f715..0763e1375c 100644
--- a/beacon-chain/node/config_test.go
+++ b/beacon-chain/node/config_test.go
@@ -3,7 +3,9 @@ package node
 import (
 	"flag"
 	"fmt"
+	"os"
 	"strconv"
+	"strings"
 	"testing"
 
 	"github.com/ethereum/go-ethereum/common"
@@ -144,6 +146,42 @@ func TestConfigureNetwork(t *testing.T) {
 	assert.Equal(t, uint64(100), params.BeaconNetworkConfig().ContractDeploymentBlock)
 }
 
+func TestConfigureNetwork_ConfigFile(t *testing.T) {
+	app := cli.App{}
+	set := flag.NewFlagSet("test", 0)
+	context := cli.NewContext(&app, set, nil)
+
+	require.NoError(t, os.WriteFile("flags_test.yaml", []byte(fmt.Sprintf("%s:\n - %s\n - %s\n", cmd.BootstrapNode.Name,
+		"node1",
+		"node2")), 0666))
+
+	require.NoError(t, set.Parse([]string{"test-command", "--" + cmd.ConfigFileFlag.Name, "flags_test.yaml"}))
+	command := &cli.Command{
+		Name: "test-command",
+		Flags: cmd.WrapFlags([]cli.Flag{
+			&cli.StringFlag{
+				Name: cmd.ConfigFileFlag.Name,
+			},
+			&cli.StringSliceFlag{
+				Name: cmd.BootstrapNode.Name,
+			},
+		}),
+		Before: func(cliCtx *cli.Context) error {
+			return cmd.LoadFlagsFromConfig(cliCtx, cliCtx.Command.Flags)
+		},
+		Action: func(cliCtx *cli.Context) error {
+			//TODO: https://github.com/urfave/cli/issues/1197 right now does not set flag
+			require.Equal(t, false, cliCtx.IsSet(cmd.BootstrapNode.Name))
+
+			require.Equal(t, strings.Join([]string{"node1", "node2"}, ","),
+				strings.Join(cliCtx.StringSlice(cmd.BootstrapNode.Name), ","))
+			return nil
+		},
+	}
+	require.NoError(t, command.Run(context))
+	require.NoError(t, os.Remove("flags_test.yaml"))
+}
+
 func TestConfigureInterop(t *testing.T) {
 	params.SetupTestConfigCleanup(t)
 
diff --git a/cmd/validator/flags/flags_test.go b/cmd/validator/flags/flags_test.go
index bf7c65ade4..f77acc4aa1 100644
--- a/cmd/validator/flags/flags_test.go
+++ b/cmd/validator/flags/flags_test.go
@@ -39,6 +39,9 @@ func TestLoadFlagsFromConfig_PreProcessing_Web3signer(t *testing.T) {
 			return cmd.LoadFlagsFromConfig(cliCtx, cliCtx.Command.Flags)
 		},
 		Action: func(cliCtx *cli.Context) error {
+			//TODO: https://github.com/urfave/cli/issues/1197 right now does not set flag
+			require.Equal(t, false, cliCtx.IsSet(Web3SignerPublicValidatorKeysFlag.Name))
+
 			require.Equal(t, strings.Join([]string{pubkey1, pubkey2}, ","),
 				strings.Join(cliCtx.StringSlice(Web3SignerPublicValidatorKeysFlag.Name), ","))
 			return nil
diff --git a/container/slice/BUILD.bazel b/container/slice/BUILD.bazel
index 84eb911f56..9e3e2c1b9a 100644
--- a/container/slice/BUILD.bazel
+++ b/container/slice/BUILD.bazel
@@ -18,5 +18,6 @@ go_test(
     deps = [
         ":go_default_library",
         "//consensus-types/primitives:go_default_library",
+        "//testing/require:go_default_library",
     ],
 )
diff --git a/container/slice/slice.go b/container/slice/slice.go
index d0f3a18f45..83e0727090 100644
--- a/container/slice/slice.go
+++ b/container/slice/slice.go
@@ -363,3 +363,21 @@ func IsInSlots(a types.Slot, b []types.Slot) bool {
 	}
 	return false
 }
+
+// Unique returns an array with duplicates filtered based on the type given
+func Unique(a []string) []string {
+	if a == nil || len(a) <= 1 {
+		return a
+	}
+	found := map[string]bool{}
+	result := make([]string, len(a))
+	end := 0
+	for i := 0; i < len(a); i++ {
+		if !found[a[i]] {
+			found[a[i]] = true
+			result[end] = a[i]
+			end += 1
+		}
+	}
+	return result[:end]
+}
diff --git a/container/slice/slice_test.go b/container/slice/slice_test.go
index ad41f900b7..db7d6bb71f 100644
--- a/container/slice/slice_test.go
+++ b/container/slice/slice_test.go
@@ -7,6 +7,7 @@ import (
 
 	types "github.com/prysmaticlabs/prysm/consensus-types/primitives"
 	"github.com/prysmaticlabs/prysm/container/slice"
+	"github.com/prysmaticlabs/prysm/testing/require"
 )
 
 func TestSubsetUint64(t *testing.T) {
@@ -587,3 +588,10 @@ func TestIsInSlots(t *testing.T) {
 		}
 	}
 }
+
+func TestUnique(t *testing.T) {
+	t.Run("string", func(t *testing.T) {
+		result := slice.Unique([]string{"a", "b", "a"})
+		require.DeepEqual(t, []string{"a", "b"}, result)
+	})
+}
diff --git a/validator/node/BUILD.bazel b/validator/node/BUILD.bazel
index 2fd449860b..f38e6f89dd 100644
--- a/validator/node/BUILD.bazel
+++ b/validator/node/BUILD.bazel
@@ -46,6 +46,7 @@ go_library(
         "//config/fieldparams:go_default_library",
         "//config/params:go_default_library",
         "//config/validator/service:go_default_library",
+        "//container/slice:go_default_library",
         "//encoding/bytesutil:go_default_library",
         "//io/file:go_default_library",
         "//monitoring/backup:go_default_library",
diff --git a/validator/node/node.go b/validator/node/node.go
index 4090e15b58..51c14c0f9f 100644
--- a/validator/node/node.go
+++ b/validator/node/node.go
@@ -31,6 +31,7 @@ import (
 	fieldparams "github.com/prysmaticlabs/prysm/config/fieldparams"
 	"github.com/prysmaticlabs/prysm/config/params"
 	validatorServiceConfig "github.com/prysmaticlabs/prysm/config/validator/service"
+	"github.com/prysmaticlabs/prysm/container/slice"
 	"github.com/prysmaticlabs/prysm/encoding/bytesutil"
 	"github.com/prysmaticlabs/prysm/io/file"
 	"github.com/prysmaticlabs/prysm/monitoring/backup"
@@ -456,8 +457,8 @@ func web3SignerConfig(cliCtx *cli.Context) (*remoteweb3signer.SetupConfig, error
 		if cliCtx.IsSet(flags.WalletPasswordFileFlag.Name) {
 			log.Warnf("%s was provided while using web3signer and will be ignored", flags.WalletPasswordFileFlag.Name)
 		}
-		if cliCtx.IsSet(flags.Web3SignerPublicValidatorKeysFlag.Name) {
-			publicKeysSlice := cliCtx.StringSlice(flags.Web3SignerPublicValidatorKeysFlag.Name)
+
+		if publicKeysSlice := cliCtx.StringSlice(flags.Web3SignerPublicValidatorKeysFlag.Name); len(publicKeysSlice) > 0 {
 			pks := make([]string, 0)
 			if len(publicKeysSlice) == 1 {
 				pURL, err := url.ParseRequestURI(publicKeysSlice[0])
@@ -470,6 +471,7 @@ func web3SignerConfig(cliCtx *cli.Context) (*remoteweb3signer.SetupConfig, error
 				pks = publicKeysSlice
 			}
 			if len(pks) > 0 {
+				pks = slice.Unique(pks)
 				var validatorKeys [][48]byte
 				for _, key := range pks {
 					decodedKey, decodeErr := hexutil.Decode(key)