diff --git a/crates/rlp/rlp-derive/src/de.rs b/crates/rlp/rlp-derive/src/de.rs
index f4edfa7df9..d9c48989fc 100644
--- a/crates/rlp/rlp-derive/src/de.rs
+++ b/crates/rlp/rlp-derive/src/de.rs
@@ -2,7 +2,7 @@ use proc_macro2::TokenStream;
 use quote::quote;
 use syn::{Error, Result};
 
-use crate::utils::{attributes_include, field_ident, is_optional, parse_struct};
+use crate::utils::{attributes_include, field_ident, is_optional, parse_struct, EMPTY_STRING_CODE};
 
 pub(crate) fn impl_decodable(ast: &syn::DeriveInput) -> Result<TokenStream> {
     let body = parse_struct(ast, "RlpDecodable")?;
@@ -107,7 +107,12 @@ fn decodable_field(index: usize, field: &syn::Field, is_opt: bool) -> TokenStrea
     } else if is_opt {
         quote! {
             #ident: if started_len - b.len() < rlp_head.payload_length {
-                Some(reth_rlp::Decodable::decode(b)?)
+                if b.first().map(|b| *b == #EMPTY_STRING_CODE).unwrap_or_default() {
+                    bytes::Buf::advance(b, 1);
+                    None
+                } else {
+                    Some(reth_rlp::Decodable::decode(b)?)
+                }
             } else {
                 None
             },
diff --git a/crates/rlp/rlp-derive/src/en.rs b/crates/rlp/rlp-derive/src/en.rs
index ff3c1f10e7..04263c0066 100644
--- a/crates/rlp/rlp-derive/src/en.rs
+++ b/crates/rlp/rlp-derive/src/en.rs
@@ -1,24 +1,28 @@
+use std::iter::Peekable;
+
 use proc_macro2::TokenStream;
 use quote::quote;
 use syn::{Error, Result};
 
-use crate::utils::{attributes_include, field_ident, is_optional, parse_struct};
+use crate::utils::{attributes_include, field_ident, is_optional, parse_struct, EMPTY_STRING_CODE};
 
 pub(crate) fn impl_encodable(ast: &syn::DeriveInput) -> Result<TokenStream> {
     let body = parse_struct(ast, "RlpEncodable")?;
 
-    let fields = body
+    let mut fields = body
         .fields
         .iter()
         .enumerate()
-        .filter(|(_, field)| !attributes_include(&field.attrs, "skip"));
+        .filter(|(_, field)| !attributes_include(&field.attrs, "skip"))
+        .peekable();
 
     let supports_trailing_opt = attributes_include(&ast.attrs, "trailing");
 
     let mut encountered_opt_item = false;
     let mut length_stmts = Vec::with_capacity(body.fields.len());
     let mut stmts = Vec::with_capacity(body.fields.len());
-    for (i, field) in fields {
+
+    while let Some((i, field)) = fields.next() {
         let is_opt = is_optional(field);
         if is_opt {
             if !supports_trailing_opt {
@@ -29,8 +33,8 @@ pub(crate) fn impl_encodable(ast: &syn::DeriveInput) -> Result<TokenStream> {
             return Err(Error::new_spanned(field, "All subsequent fields must be optional."))
         }
 
-        length_stmts.push(encodable_length(i, field, is_opt));
-        stmts.push(encodable_field(i, field, is_opt));
+        length_stmts.push(encodable_length(i, field, is_opt, fields.clone()));
+        stmts.push(encodable_field(i, field, is_opt, fields.clone()));
     }
 
     let name = &ast.ident;
@@ -131,11 +135,23 @@ pub(crate) fn impl_max_encoded_len(ast: &syn::DeriveInput) -> Result<TokenStream
     })
 }
 
-fn encodable_length(index: usize, field: &syn::Field, is_opt: bool) -> TokenStream {
+fn encodable_length<'a>(
+    index: usize,
+    field: &syn::Field,
+    is_opt: bool,
+    mut remaining: Peekable<impl Iterator<Item = (usize, &'a syn::Field)>>,
+) -> TokenStream {
     let ident = field_ident(index, field);
 
     if is_opt {
-        quote! { rlp_head.payload_length += &self.#ident.as_ref().map(|val| reth_rlp::Encodable::length(val)).unwrap_or_default(); }
+        let default = if remaining.peek().is_some() {
+            let condition = remaining_opt_fields_some_condition(remaining);
+            quote! { #condition as usize }
+        } else {
+            quote! { 0 }
+        };
+
+        quote! { rlp_head.payload_length += &self.#ident.as_ref().map(|val| reth_rlp::Encodable::length(val)).unwrap_or(#default); }
     } else {
         quote! { rlp_head.payload_length += reth_rlp::Encodable::length(&self.#ident); }
     }
@@ -151,12 +167,43 @@ fn encodable_max_length(index: usize, field: &syn::Field) -> TokenStream {
     }
 }
 
-fn encodable_field(index: usize, field: &syn::Field, is_opt: bool) -> TokenStream {
+fn encodable_field<'a>(
+    index: usize,
+    field: &syn::Field,
+    is_opt: bool,
+    mut remaining: Peekable<impl Iterator<Item = (usize, &'a syn::Field)>>,
+) -> TokenStream {
     let ident = field_ident(index, field);
 
     if is_opt {
-        quote! { self.#ident.as_ref().map(|val| reth_rlp::Encodable::encode(val, out)); }
+        let if_some_encode = quote! {
+            if let Some(val) = self.#ident.as_ref() {
+                reth_rlp::Encodable::encode(val, out)
+            }
+        };
+
+        if remaining.peek().is_some() {
+            let condition = remaining_opt_fields_some_condition(remaining);
+            quote! {
+                #if_some_encode
+                else if #condition {
+                    out.put_u8(#EMPTY_STRING_CODE);
+                }
+            }
+        } else {
+            quote! { #if_some_encode }
+        }
     } else {
         quote! { reth_rlp::Encodable::encode(&self.#ident, out); }
     }
 }
+
+fn remaining_opt_fields_some_condition<'a>(
+    remaining: impl Iterator<Item = (usize, &'a syn::Field)>,
+) -> TokenStream {
+    let conditions = remaining.map(|(index, field)| {
+        let ident = field_ident(index, field);
+        quote! { self.#ident.is_some() }
+    });
+    quote! { #(#conditions) ||* }
+}
diff --git a/crates/rlp/rlp-derive/src/utils.rs b/crates/rlp/rlp-derive/src/utils.rs
index 3e5f373059..1897f7f0ce 100644
--- a/crates/rlp/rlp-derive/src/utils.rs
+++ b/crates/rlp/rlp-derive/src/utils.rs
@@ -2,6 +2,8 @@ use proc_macro2::TokenStream;
 use quote::quote;
 use syn::{Attribute, DataStruct, Error, Field, Meta, NestedMeta, Result, Type, TypePath};
 
+pub(crate) const EMPTY_STRING_CODE: u8 = 0x80;
+
 pub(crate) fn parse_struct<'a>(
     ast: &'a syn::DeriveInput,
     derive_attr: &str,
diff --git a/crates/rlp/tests/rlp.rs b/crates/rlp/tests/rlp.rs
index 7f82b59094..c7c3e52e41 100644
--- a/crates/rlp/tests/rlp.rs
+++ b/crates/rlp/tests/rlp.rs
@@ -127,4 +127,9 @@ fn test_opt_fields_roundtrip() {
     let item = TestOpt { a: 1, b: 2, c: Some(3), d: Some(4) };
     assert_eq!(&*encoded(&item), expected);
     assert_eq!(TestOpt::decode(&mut &expected[..]).unwrap(), item);
+
+    let expected = hex!("c401028004");
+    let item = TestOpt { a: 1, b: 2, c: None, d: Some(4) };
+    assert_eq!(&*encoded(&item), expected);
+    assert_eq!(TestOpt::decode(&mut &expected[..]).unwrap(), item);
 }